FDA-approved treatment
Spravato® (Esketamine) Treatment for Depression
For people who haven’t found relief with traditional antidepressants. Spravato nasal spray is a groundbreaking therapy that can provide rapid relief from severe depression.
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Approximately 70% of patients experience a clinically meaningful
response to treatment for treatment-resistant depression.
What is Spravato?
Simple and noninvasive
Spravato (or esketamine) is an FDA-approved nasal spray that is quickly and simply administered in our clinic under physician supervision.
An innovative approach
Spravato targets different brain chemicals than antidepressants, making it effective when other treatments have failed.
Rapid relief
Many patients feel better within days or even hours, unlike traditional antidepressants that take weeks or months.
Covered by insurance
For those diagnosed with treatment-resistant depression or major depressive disorder, Spravato is often covered by insurance.
How Spravato works
Spravato targets different brain chemicals than conventional antidepressants.
Traditional medications target neurotransmitters like serotonin and dopamine. Spravato, on the other hand, targets glutamate, which helps your brain create new pathways and “rewire” old patterns that keep you stuck in depression.
- Serotonin
- Dopamine
- Glutamate
What to expect from your first Spravato treatment session
- Keep hydrated, eat healthy meals and get a good night’s sleep.
- Avoid alcohol, marijuana or other substances in the days before your session.
- Take time for meditation, journaling or other relaxation techniques.
- The nurse will take your vitals and review your medical information.
- Settle in with music or reading to allow yourself to relax.
- You may experience intense emotions and a dreamlike state.
- Slight dizziness and nausea are normal and fleeting.
- Our medical team will support you during the 2-hour session.
- Relax in our spa like room
- Enjoy drinks and light refreshments from our snack bar
- The doctor will make sure you’re ready to leave.
- Arrange for transportation home.
What our patients are saying
Care you can trust
Your comfort and safety are at the center of everything we do. Spravato treatment at Keta Medical Center is:
Spravato is an FDA-approved, evidence-based treatment.
Designed specifically for you, based on your mental health history, your needs, and how you respond in each session.
Experienced ER doctors and nurses oversee every treatment session.
Spravato treatment & integrated care beyond medication
Spravato works powerfully on its own, but it works even better as part of comprehensive care.
If you need caring, timely support for your Spravato treatment, our experienced in-house psychiatrists are here to guide you.
Spravato can unlock new insights and perspectives. Research shows that ketamine-assisted psychotherapy helps you integrate them into your life.
We offer PRISM, a groundbreaking, noninvasive, FDA-cleared therapy designed specifically for patients with PTSD.
Is Spravato right for you?
Who is (and isn’t) a suitable Spravato candidate?
Here are the basic guidelines, but the real answer comes from a conversation with our doctors.
- Are feeling down, depressed or hopeless
- Have little interest or pleasure in doing things
- Have little energy and trouble concentrating on things
- Have tried medication and talk therapy without success
- Had a brain aneurysm or brain bleed
- Experienced psychosis or are in an active manic episode
- Women who are pregnant or trying to get pregnant
- Are engaged in active illicit substance abuse
Find out if Spravato can help you.
Research
Below are several studies about the effectiveness of esketamine in treating depression. Ketamine-based therapy is a subject of ongoing research and is frequently covered in both mainstream media and scientific journals.
Johns Hopkins Medicine
National Library of Medicine
FAQs
If you take Spravato as prescribed and in a professional medical setting, it is safe to use. Patients with a history of uncontrolled hypertension, brain mass or bleed may not be appropriate candidates for ketamine treatment. If you are pregnant or breastfeeding, please consult with your physician.
Many patients report improvement in their symptoms within hours of their first session.
The response varies by individual, but rapid relief is a key benefit of ketamine therapy, especially for those with treatment-resistant conditions. Studies show that 70% of people respond to the treatment and 52% of patients achieved full remission of their depression symptoms after four weeks of treatment.
The side effects of Spravato can include mild nausea, dizziness, feelings of dissociation, anxiety or increased blood pressure. These typically resolve shortly after the treatment session. Our medical team monitors patients closely to manage any side effects effectively.
The induction phase includes 8 treatments delivered over 4 weeks. Each Spravato treatment lasts two hours. Following induction, patients move into the optimization phase and come once a month, then transition to a maintenance phase tailored to individual needs.
When Spravato treatment is administered as prescribed in a controlled medical setting, the risk of addiction is very low. Keta Medical Center provides physician supervision and close monitoring during each session to ensure safe use.
If you have a diagnosis of treatment‑resistant depression and have previously tried two or more antidepressant treatments, you may be eligible for Spravato. Keta Medical Center will review your treatment history during a consultation and verify insurance coverage to confirm eligibility and next steps.
No, Spravato requires administration under direct medical supervision in a certified therapy center as mandated by the FDA. Patients are monitored for potential side effects such as increased blood pressure and require an observation period after dosing. Keta Medical Center provides on‑site physician and nursing oversight throughout the session to ensure safety and well‑being.
Our medical director will conduct a consultation and medical screening to review your diagnosis, prior treatment history, current medications, and overall health, and recommend the most appropriate option. Insurance coverage may also play a role in determining the best path forward. Spravato is covered by most major insurance plans, and our team handles all verification, paperwork, and prior authorizations on your behalf. IV ketamine infusions are not typically covered by insurance, though flexible payment options are available.
Not sure yet?
Explore the resources on our site to find out how ketamine treatment can help you heal.