Ketamine may be a very good option for those who cannot tolerate standard medications. It can also be helpful in patients that have not improved or plateaued with standard oral medications.
Ketamine has a different mechanism to anxiety medications. While antidepressants typically increase serotonin levels over time, ketamine briefly blocks NMDA receptors which trigger a surge of glutamate activity that helps the brain create new pathways that improve communication between brain cells and “reset” behavioral patterns linked to anxiety disorders.
Because ketamine works differently in the brain than anxiety medication, it can be an option for patients who don’t tolerate or respond to typical anxiety medications.